Green Bay Packers running back MarShawn Lloyd seems to have suffered yet another setback in his long-running quest to return to the football field.

The Packers officially ruled out Lloyd for Week 15’s game against the Denver Broncos when they released their final injury report on December 12, a move that is not entirely surprising given that he is still in his 21-day window to return from injured reserve.

What was surprising, however, was the Packers adding a “hamstring” injury for Lloyd on the injury report in addition to the previous calf injury that landed him on injured reserve on August 26 during the 53-man roster cutdown after NFL training camp.

The pair of injuries also kept Lloyd off the practice field for the final walkthrough for the Broncos on December 12, marking the first time he has missed a practice since the Packers designated him for return on December 1. The new calf injury also raises the possibility that Lloyd’s second NFL season could be over without him playing a snap.

The Packers could also be without their starting tailback, Josh Jacobs, when they face the Broncos on the road. Jacobs is questionable with a knee injury that held him out of the week’s first two practices, but he did notably end the week as a limited participant.

The Packers (9-3-1) will kick off against the Broncos (11-2) at 4:25 p.m. ET on Sunday, December 14.